https://www.cureus.com/articles/175337-harnessing-the-therapeutic-potential-of-stem-cells-in-the-management-of-chronic-obstructive-pulmonary-disease-a-comprehensive-review#!/
Research
Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts
https://www.nejm.org/doi/full/10.1056/NEJMoa2303951
Unleashing the Power of IL-17: A Promising Frontier in Chronic Obstructive Pulmonary Disease (COPD) Treatment
https://www.cureus.com/articles/167789-unleashing-the-power-of-il-17-a-promising-frontier-in-chronic-obstructive-pulmonary-disease-copd-treatment#!/
Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01347-7 https://www.ncbi.nlm.nih.gov/pubmed/32907566?dopt=Abstract Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator. Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator. Respir […]
Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial
https://www.cell.com/heliyon/fulltext/S2405-8440(20)31554-1 https://www.ncbi.nlm.nih.gov/pubmed/32904114?dopt=Abstract Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial. Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial. Heliyon. 2020 Aug;6(8):e04711 Authors: Al-Azzawi MA, AboZaid MMN, Ibrahem RAL, Sakr MA Abstract […]
Biomarkers in Chronic Obstructive Pulmonary Disease: The Gateway to Precision Medicine
https://www.sciencedirect.com/science/article/abs/pii/S0272523120300344?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32800193?dopt=Abstract Biomarkers in Chronic Obstructive Pulmonary Disease: The Gateway to Precision Medicine. Biomarkers in Chronic Obstructive Pulmonary Disease: The Gateway to Precision Medicine. Clin Chest Med. 2020 Sep;41(3):383-394 Authors: Milne S, Sin DD Abstract Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease with limited adequate treatments. Biomarkers-which may relate to disease susceptibility, […]
The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease
https://www.preprints.org/manuscript/202008.0260/v1 The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease Jingyuan Li and Zuguang Ye * Version 1 : Received: 10 August 2020 / Approved: 11 August 2020 / Online: 11 August 2020 (09:20:57 CEST)
Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease.
https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202000632R https://www.ncbi.nlm.nih.gov/pubmed/32780913?dopt=Abstract Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease. Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease. FASEB J. 2020 Aug 11;: Authors: Wu SM, Feng PH, Chuang HC, Ho SC, Fan Chung K, […]
Preventive and therapeutic effectiveness of Sanfu acupoint herbal patching for chronic obstructive pulmonary disease at stable stages: a systematic review and meta-analysis
https://kns.cnki.net/kcms/detail/detail.aspx?doi=10.19852/j.cnki.jtcm.2020.04.003 https://www.ncbi.nlm.nih.gov/pubmed/32744021?dopt=Abstract Preventive and therapeutic effectiveness of Sanfu acupoint herbal patching for chronic obstructive pulmonary disease at stable stages: a systematic review and Meta-analysis. Related Articles Preventive and therapeutic effectiveness of Sanfu acupoint herbal patching for chronic obstructive pulmonary disease at stable stages: a systematic review and Meta-analysis. J Tradit Chin Med. 2020 Aug;40(4):530-549 Authors: […]
Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy
https://www.resmedjournal.com/article/S0954-6111(20)30238-9/fulltext https://www.ncbi.nlm.nih.gov/pubmed/32777683?dopt=Abstract Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy. Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy. Respir Med. 2020 Jul 30;171:106098 Authors: Mallah H, Ball S, Sekhon J, Parmar K, Nugent K Abstract Platelets are essential mediators of inflammation […]
Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence
https://www.tandfonline.com/doi/abs/10.1080/15412555.2020.1797657?journalCode=icop20 https://www.ncbi.nlm.nih.gov/pubmed/32722945?dopt=Abstract Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. Related Articles Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD. 2020 Jul 28;:1-8 Authors: Gu C, Zhang Q, Ni D, […]
Difference in the metabolic characteristics of chronic obstructive pulmonary disease patients and healthy adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386978/ https://www.ncbi.nlm.nih.gov/pubmed/32791715?dopt=Abstract Difference in the metabolic characteristics of chronic obstructive pulmonary disease patients and healthy adults. Related Articles Difference in the metabolic characteristics of chronic obstructive pulmonary disease patients and healthy adults. Medicine (Baltimore). 2020 Jul 24;99(30):e21302 Authors: Jiang Y, Hu H, Li X, He X, Shao X, Lou J, Zhang Y, Wu Y, Fang […]
ADAM15 deficiency increased pulmonary inflammation in mice and is strongly linked to the pathogenesis of COPD
https://www.nature.com/articles/s41385-020-0325-3 https://www.ncbi.nlm.nih.gov/pubmed/32690871?dopt=Abstract A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice. ADAM15 deficiency increased pulmonary inflammation in mice and is strongly linked to the pathogenesis of COPD Related Articles A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like […]
Fecal microbial transplantation (FMT) and a high fiber diet (HFD) attenuates emphysema development by suppressing inflammation and apoptosis
https://www.nature.com/articles/s12276-020-0469-y https://www.ncbi.nlm.nih.gov/pubmed/32681029?dopt=Abstract Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis. Related Articles Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis. Exp Mol Med. 2020 Jul 17;: Authors: Jang YO, Lee SH, Choi JJ, Kim DH, Choi JM, Kang MJ, […]
ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01446-5 https://www.ncbi.nlm.nih.gov/pubmed/32677970?dopt=Abstract ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction. Related Articles ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction. Respir […]
Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202008379 https://www.ncbi.nlm.nih.gov/pubmed/32666703?dopt=Abstract Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. Related Articles Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. Angew Chem Int Ed Engl. 2020 Jul 15;: Authors: Li Z, Luo G, Hu WP, […]
Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study
https://www.frontiersin.org/articles/10.3389/fnins.2020.00740/full https://www.ncbi.nlm.nih.gov/pubmed/32760247?dopt=Abstract Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation. Related Articles Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation. Front Neurosci. 2020;14:740 Authors: Paulin FV, Goelzer LS, Müller PT Abstract […]
PR1P as a novel therapeutic agent for the treatment of emphysema or other lung diseases characterized by VEGF signaling dysregulation
https://www.atsjournals.org/doi/10.1165/rcmb.2019-0434OC https://www.ncbi.nlm.nih.gov/pubmed/32663413?dopt=Abstract PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema. Related Articles PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema. Am J Respir Cell Mol Biol. 2020 Jul 14;: Authors: Adini A, Wu H, Dao DT, Ko VH, Yu LJ, Pan A, Puder M, Mitiku […]
Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD
https://www.nejm.org/doi/full/10.1056/NEJMoa1916046 Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD
Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis
https://www.sciencedirect.com/science/article/pii/S0753332220305187?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32768929?dopt=Abstract Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. Related Articles Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. Biomed Pharmacother. 2020 Jul 02;129:110326 Authors: Mei J, Zhang Y, Lu […]
The Role of Toll-Like Receptors 2 (TLR2) and 4 (TLR4) in the Pathogenesis of Chronic Obstructive Pulmonary Disease
https://www.dovepress.com/the-role-of-toll-like-receptors-2-and-4-in-the-pathogenesis-of-chronic-peer-reviewed-fulltext-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/32606656?dopt=Abstract The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Related Articles The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2020;15:1481-1493 Authors: Sidletskaya K, Vitkina T, Denisenko Y Abstract Currently, chronic obstructive pulmonary […]
The Adjunctive Effect of Intravenous Magnesium Sulfate in Acute Exacerbation of COPD
https://www.ncbi.nlm.nih.gov/pubmed/32542879?dopt=Abstract The Adjunctive Effect of Intravenous Magnesium Sulfate in Acute Exacerbation of COPD: A Randomized Controlled Clinical Trial. The Adjunctive Effect of Intravenous Magnesium Sulfate in Acute Exacerbation of COPD: A Randomized Controlled Clinical Trial. Acad Emerg Med. 2020 Jun 15;: Authors: Vafadar Moradi E, Pishbin E, Habibzadeh SR, Talebi Doluee M, Soltanifar A Abstract […]
CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01401-4 https://www.ncbi.nlm.nih.gov/pubmed/32532258?dopt=Abstract CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial. Related Articles CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial. Respir Res. 2020 Jun 12;21(1):149 Authors: Lazaar AL, Miller BE, Donald AC, Keeley T, Ambery C, Russell […]
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD
https://www.nature.com/articles/s42255-020-0215-8 https://www.ncbi.nlm.nih.gov/pubmed/32694733?dopt=Abstract NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Related Articles NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546 Authors: Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, […]
Effects of compound Caoshi silkworm granules (CCSGs) on stable COPD patients and their relationship with gut microbiota
https://journals.lww.com/md-journal/FullText/2020/05290/Effects_of_compound_Caoshi_silkworm_granules_on.118.aspx https://www.ncbi.nlm.nih.gov/pubmed/32481473?dopt=Abstract Effects of compound Caoshi silkworm granules on stable COPD patients and their relationship with gut microbiota: A randomized controlled trial. Related Articles Effects of compound Caoshi silkworm granules on stable COPD patients and their relationship with gut microbiota: A randomized controlled trial. Medicine (Baltimore). 2020 May 29;99(22):e20511 Authors: Hu Y, Shi Q, Ying […]
The Relevance of Targeting Treatment to Small Airways in Asthma and COPD: the newest technological therapeutic advances
https://www.ncbi.nlm.nih.gov/pubmed/32209703?dopt=Abstract http://rc.rcjournal.com/content/early/2020/03/24/respcare.07237 The Relevance of Targeting Treatment to Small Airways in Asthma and COPD. Related Articles The Relevance of Targeting Treatment to Small Airways in Asthma and COPD. Respir Care. 2020 Mar 24;: Authors: Santus P, Radovanovic D, Pecchiari M, Ferrando M, Tursi F, Patella V, Braido F Abstract COPD and asthma have different risk […]
Hesperidin alleviated inflammation and oxidative stress responses in COPD mice, associated with SIRT1/PGC-1α/NF-κB signaling axis: a new direction for COPD treatment
https://www.tandfonline.com/doi/abs/10.1080/10799893.2020.1738483?journalCode=irst20 https://www.ncbi.nlm.nih.gov/pubmed/32164488?dopt=Abstract Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis. Hesperidin alleviated inflammation and oxidative stress responses in COPD mice, associated with SIRT1/PGC-1α/NF-κB signaling axis: a new direction for COPD treatment J Recept Signal Transduct Res. 2020 Mar 13;:1-7 Authors: Wang S, He N, […]
The Efficacy of Lung Volume Reduction Coil Treatment in Patients with Severe Chronic Obstructive Pulmonary Disease (COPD) Type II Respiratory Failure
https://www.dovepress.com/the-efficacy-of-lung-volume-reduction-coil-treatment-in-patients-with–peer-reviewed-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/32184585?dopt=Abstract The Efficacy of Lung Volume Reduction Coil Treatment in Patients with Severe Chronic Obstructive Pulmonary Disease (COPD) Type II Respiratory Failure. Related Articles The Efficacy of Lung Volume Reduction Coil Treatment in Patients with Severe Chronic Obstructive Pulmonary Disease (COPD) Type II Respiratory Failure. Int J Chron Obstruct Pulmon Dis. 2020;15:479-486 Authors: Yildiz […]
The key role of macrophage depolarization in the treatment of COPD with ergosterol
https://www.sciencedirect.com/science/article/pii/S1567576919322933?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31874368?dopt=Abstract The key role of macrophage depolarization in the treatment of COPD with ergosterol both in vitro and in vivo. The key role of macrophage depolarization in the treatment of COPD with ergosterol both in vitro and in vivo. Int Immunopharmacol. 2019 Dec 20;79:106086 Authors: Sun X, Liu Y, Feng X, Li C, Li […]
Bu-Shen-Fang-Chuan formula (BSFCF) attenuates T-lymphocytes recruitment and improves pulmonary function in rat model of COPD through suppressing CXCL9/CXCL10/CXCL11-CXCR3 axis
https://www.ncbi.nlm.nih.gov/pubmed/31864210?dopt=Abstract Bu-Shen-Fang-Chuan formula attenuates T-lymphocytes recruitment in the lung of rats with COPD through suppressing CXCL9/CXCL10/CXCL11-CXCR3 axis. improved pulmonary function and attenuated CD8+ T-cells recruitment in rat model of COPD Bu-Shen-Fang-Chuan formula attenuates T-lymphocytes recruitment in the lung of rats with COPD through suppressing CXCL9/CXCL10/CXCL11-CXCR3 axis. Biomed Pharmacother. 2019 Dec 17;123:109735 Authors: Li Q, Sun […]
Oral formulation angiotensin-(1-7) therapy attenuates pulmonary and systemics damage in mice with emphysema
https://www.sciencedirect.com/science/article/pii/S0171298519302086?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31837773?dopt=Abstract Oral formulation angiotensin-(1-7) therapy attenuates pulmonary and systemics damage in mice with emphysema induced by elastase. Related Articles Oral formulation angiotensin-(1-7) therapy attenuates pulmonary and systemics damage in mice with emphysema induced by elastase. Immunobiology. 2019 Dec 04;: Authors: Bastos AC, Magalhães GS, Gregório JF, Matos NA, Motta-Santos D, Bezerra FS, Santos RAS, […]
Dynamic changes of gut and lung microorganisms during chronic obstructive pulmonary disease exacerbations: possibly a target for future therapeutics
https://onlinelibrary.wiley.com/doi/full/10.1002/kjm2.12147 https://www.ncbi.nlm.nih.gov/pubmed/31782610?dopt=Abstract Dynamic changes of gut and lung microorganisms during chronic obstructive pulmonary disease exacerbations. Dynamic changes of gut and lung microorganisms during chronic obstructive pulmonary disease exacerbations. Kaohsiung J Med Sci. 2019 Nov 29;: Authors: Sun Z, Zhu QL, Shen Y, Yan T, Zhou X Abstract Increasing evidence has indicated the intimate relationship between […]
Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol
https://bmjopen.bmj.com/content/9/11/e030249 https://www.ncbi.nlm.nih.gov/pubmed/31784433?dopt=Abstract Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controlled trial. Related Articles Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controlled […]
Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD
https://www.dovepress.com/dual-role-for-a-mek-inhibitor-as-a-modulator-of-inflammation-and-host–peer-reviewed-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/32063702?dopt=Abstract Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD. Related Articles Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:2611-2624 Authors: Kurian […]
Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14816 https://www.ncbi.nlm.nih.gov/pubmed/31762195?dopt=Abstract Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. Related Articles Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke. J Cell Mol Med. 2019 Nov 25;: Authors: Shin NR, Ko JW, Kim JC, Park G, Kim SH, Kim […]
LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD
https://www.mdpi.com/2077-0383/8/12/2058 https://www.ncbi.nlm.nih.gov/pubmed/31766770?dopt=Abstract LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD. Related Articles LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD. J Clin Med. 2019 Nov 22;8(12): Authors: Knobloch J, Jungck D, Kronsbein J, Stoelben E, Ito K, Koch A […]
Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art [Review]
https://www.sciencedirect.com/science/article/pii/S2531043719302089?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31740261?dopt=Abstract “Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art.” Related Articles “Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art.” Pulmonology. 2019 Nov 15;: Authors: Corlateanu A, Mendez Y, Wang Y, Garnica RJA, Botnaru V, Siafakas N Abstract Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystemic disease with progressive increasing morbidity and mortality. […]
Acumapimod (BCT197) to Treat Acute Exacerbations of COPD
https://www.tandfonline.com/doi/abs/10.1080/15412555.2019.1682535?journalCode=icop20 https://www.ncbi.nlm.nih.gov/pubmed/31682162?dopt=Abstract Phase II Study of Single/Repeated Doses of Acumapimod (BCT197) to Treat Acute Exacerbations of COPD. Phase II Study of Single/Repeated Doses of Acumapimod (BCT197) to Treat Acute Exacerbations of COPD. COPD. 2019 Nov 04;:1-10 Authors: Strâmbu IR, Kobalava ZD, Magnusson BP, MacKinnon A, Parkin JM Abstract Mitogen-activated protein kinase p38 is a key […]
Inhibitors of ErbB kinases have therapeutic potential in neutrophilic inflammatory diseases, including chronic obstructive pulmonary disease (COPD)
https://elifesciences.org/articles/50990 Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation Inhibitors of ErbB kinases have therapeutic potential in neutrophilic inflammatory diseases, including chronic obstructive pulmonary disease (COPD)
Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease
https://pubmed.ncbi.nlm.nih.gov/31737347-airway-pharmacology-treatment-options-and-algorithms-to-treat-patients-with-chronic-obstructive-pulmonary-disease/?dopt=Abstract http://jtd.amegroups.com/article/view/32743/22939 https://www.ncbi.nlm.nih.gov/pubmed/31737347?dopt=Abstract Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. Related Articles Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. J Thorac Dis. 2019 Oct;11(Suppl 17):S2200-S2209 Authors: Kerstjens HAM, Upham JW, Yang IA Abstract Pharmacological treatment of patients with chronic obstructive pulmonary […]
Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases
https://onlinelibrary.wiley.com/doi/abs/10.1002/wnan.1586 https://www.ncbi.nlm.nih.gov/pubmed/31602823 Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Oct 10:e1586. doi: 10.1002/wnan.1586. [Epub ahead of print] Abstract Respiratory illnesses are prevalent around the world, and inhalation-based therapies provide an attractive, noninvasive means of directly delivering therapeutic agents to their site of action to improve treatment […]
Lipids in COPD: A Target for Future Therapy? [PDF]
https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2019-0338ED https://www.ncbi.nlm.nih.gov/pubmed/31577908?dopt=Abstract Lipids in COPD: A Target for Future Therapy? Lipids in COPD: A Target for Future Therapy? Am J Respir Cell Mol Biol. 2019 Oct 02;: Authors: Vlahos R PMID: 31577908 [PubMed – as supplied by publisher] PubMed:31577908 Vlahos R
Allyl isothiocyanate (AITC) may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway
https://link.springer.com/article/10.1007%2Fs12272-019-01183-4 https://www.ncbi.nlm.nih.gov/pubmed/31571144?dopt=Abstract “targeting the Notch signaling pathway may present as an effective therapeutic strategy for COPD treatment” Allyl isothiocyanate may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway. Allyl isothiocyanate may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway. Arch Pharm Res. 2019 Sep 30;: […]
Therapeutic efficacy of the aqueous extract of the stem bark of Ximenia americana L. in the treatment of experimental COPD in rats
https://www.sciencedirect.com/science/article/pii/S037887411932728X?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31577938?dopt=Abstract Phytochemical study, molecular docking, genotoxicity and therapeutic efficacy of the aqueous extract of the stem bark of Ximenia americana L. in the treatment of experimental COPD in rats. Phytochemical study, molecular docking, genotoxicity and therapeutic efficacy of the aqueous extract of the stem bark of Ximenia americana L. in the treatment of experimental […]
DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough
hhttps://journals.sagepub.com/doi/10.1177/1753466619877960 ttps://www.ncbi.nlm.nih.gov/pubmed/31558105?dopt=Abstract DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough. Related Articles DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619877960 Authors: Pelleg A, Xu F, Zhuang J, Undem B, Burnstock G Abstract BACKGROUND: Extracellular adenosine 5′-triphosphate (ATP) plays important mechanistic roles […]
COPD: preclinical models and emerging therapeutic targets
https://www.tandfonline.com/doi/abs/10.1080/14728222.2019.1667976?journalCode=iett20 https://www.ncbi.nlm.nih.gov/pubmed/31512957?dopt=Abstract COPD: preclinical models and emerging therapeutic targets. COPD: preclinical models and emerging therapeutic targets. Expert Opin Ther Targets. 2019 Sep 12;: Authors: Barreiro E, Wang X, Tang J Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In […]
Dissection of Pharmacological Mechanism of Chinese Herbal Medicine Yihuo Huatan Formula on Chronic Obstructive Pulmonary Disease
https://www.nature.com/articles/s41598-019-50064-9 https://www.ncbi.nlm.nih.gov/pubmed/31530860?dopt=Abstract Dissection of Pharmacological Mechanism of Chinese Herbal Medicine Yihuo Huatan Formula on Chronic Obstructive Pulmonary Disease: A Systems Pharmacology-Based Study. Dissection of Pharmacological Mechanism of Chinese Herbal Medicine Yihuo Huatan Formula on Chronic Obstructive Pulmonary Disease: A Systems Pharmacology-Based Study. Sci Rep. 2019 Sep 17;9(1):13431 Authors: Zhang XW, Liu W, Jiang HL, Mao […]
Carbocisteine inhibits the expression of Muc5b in COPD mouse model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754527/ https://www.dovepress.com/carbocisteine-inhibits-the-expression-of-muc5b-in-copd-mouse-model-peer-reviewed-article-DDDT https://www.ncbi.nlm.nih.gov/pubmed/31571828?dopt=Abstract “carbocisteine attenuated Muc5b and Muc5ac secretion and restored Muc5b protein levels, which may improve mucus clearance in COPD” Carbocisteine inhibits the expression of Muc5b in COPD mouse model. Carbocisteine inhibits the expression of Muc5b in COPD mouse model. Drug Des Devel Ther. 2019;13:3259-3268 Authors: Song Y, Wang W, Xie Y, Xiang B, […]
Anti-viral immunity is impaired in COPD patients with frequent exacerbations
https://www.physiology.org/doi/abs/10.1152/ajplung.00253.2019 https://www.ncbi.nlm.nih.gov/pubmed/31513433?dopt=Abstract Anti-viral immunity is impaired in COPD patients with frequent exacerbations. Anti-viral immunity is impaired in COPD patients with frequent exacerbations. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 12;: Authors: Singanayagam A, Loo SL, Calderazzo MA, Finney LJ, Trujillo Torralbo MB, Bakhsoliani E, Girkin J, Veerati PC, Pathinayake PS, Nichol KS, Reid […]
Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model
https://journals.sagepub.com/doi/10.1177/0300060519869459 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833429/ https://www.ncbi.nlm.nih.gov/pubmed/31510839?dopt=Abstract Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model. Related Articles Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model. J Int Med Res. 2019 Oct;47(10):4764-4774 Authors: Tang […]
miRNA‑101‑3p.1 facilitates COPD progression by activating the EGFR/PI3K/AKT signaling pathway
https://www.spandidos-publications.com/10.3892/mmr.2019.10657 https://www.ncbi.nlm.nih.gov/pubmed/31545413?dopt=Abstract miRNA‑101‑3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway. miRNA‑101‑3p.1 as an independent diagnostic biomarker aggravates chronic obstructive pulmonary disease via activation of the EGFR/PI3K/AKT signaling pathway. Mol Med Rep. 2019 Sep 09;: Authors: Chen S, Zhang Z, Chen L, Zhang J Abstract Exploring […]
Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732561/ https://www.dovepress.com/therapeutic-potential-of-blt1-antagonist-for-copd-involvement-of-induc-peer-reviewed-article-DDDT https://www.ncbi.nlm.nih.gov/pubmed/31564828?dopt=Abstract Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation. Related Articles Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation. Drug Des Devel Ther. 2019;13:3105-3116 Authors: Zhang L, Huang J, Dong R, Feng Y, Zhou M Abstract Purpose: Leukotriene B4 (LTB4) is […]
Immune-Modulation in Chronic Obstructive Pulmonary Disease: Current Concepts and Future Strategies
https://www.karger.com/Article/Abstract/502261 https://www.ncbi.nlm.nih.gov/pubmed/31480060?dopt=Abstract Immune-Modulation in Chronic Obstructive Pulmonary Disease: Current Concepts and Future Strategies. Immune-Modulation in Chronic Obstructive Pulmonary Disease: Current Concepts and Future Strategies. Respiration. 2019 Sep 03;:1-16 Authors: van Eeden SF, Hogg JC Abstract Chronic obstructive pulmonary disease (COPD) is caused by the chronic inhalation of toxic particles and gases that are primarily but […]
Ensifentrine (RPL554): an investigational PDE3/4 inhibitor for the treatment of COPD
https://www.ncbi.nlm.nih.gov/pubmed/31474120?dopt=Abstract https://www.ncbi.nlm.nih.gov/pubmed/31474120?dopt=Abstract Ensifentrine (RPL554): an investigational PDE3/4 inhibitor for the treatment of COPD. Related Articles Ensifentrine (RPL554): an investigational PDE3/4 inhibitor for the treatment of COPD. Expert Opin Investig Drugs. 2019 Sep 01;:1-7 Authors: Cazzola M, Calzetta L, Rogliani P, Matera MG Abstract Introduction: A compound that simultaneously inhibits PDE3 and PDE4 should increase airway […]
Pharmacological treatment and current controversies in COPD
https://f1000research.com/articles/8-1533/v1 https://www.ncbi.nlm.nih.gov/pubmed/31508197?dopt=Abstract Pharmacological treatment and current controversies in COPD. Pharmacological treatment and current controversies in COPD. F1000Res. 2019;8: Authors: Cazzola M, Rogliani P, Stolz D, Matera MG Abstract Bronchodilators, corticosteroids, and antibiotics are still key elements for treating chronic obstructive pulmonary disease in the 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations and […]
Efficacy and safety of inhaled alpha-1-antitrypsin in severe COPD patients with alpha-1-antitrypsin deficiency
https://erj.ersjournals.com/content/early/2019/08/14/13993003.00673-2019 https://www.ncbi.nlm.nih.gov/pubmed/31467115?dopt=Abstract Efficacy and safety of inhaled alpha-1-antitrypsin in patients with severe alpha-1-antitrypsin deficiency and frequent exacerbations of Chronic Obstructive Pulmonary Disease. Related Articles Efficacy and safety of inhaled alpha-1-antitrypsin in patients with severe alpha-1-antitrypsin deficiency and frequent exacerbations of Chronic Obstructive Pulmonary Disease. Eur Respir J. 2019 Aug 29;: Authors: Stolk J, Tov N, […]
CARM1 contributes to airway repair and regeneration by regulating airway epithelial cell senescence
https://www.physiology.org/doi/abs/10.1152/ajplung.00441.2018 https://www.ncbi.nlm.nih.gov/pubmed/31461302?dopt=Abstract CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 28;: Authors: Sarker RSJ, Conlon TM, Morrone C, Srivastava B, Konyalilar N, Verleden SE, Bayram H, Fehrenbach H, Yildirim AÖ Abstract Chronic […]
Wharton’s jelly-derived mesenchymal stem cells show pulmonary regenerative effects in COPD mouse model
https://www.sciencedirect.com/science/article/pii/S2352320419300227?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31489344?dopt=Abstract Effects of Wharton’s jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease. Related Articles Effects of Wharton’s jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease. Regen Ther. 2019 Dec;11:207-211 Authors: Cho JW, Park KS, Bae JY Abstract Objectives: Chronic obstructive pulmonary disease (COPD) is a fatal disease that shortens one’s life expectancy […]
Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease
https://www.dovepress.com/mepolizumab-in-the-treatment-of-eosinophilic-chronic-obstructive-pulmo-peer-reviewed-fulltext-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/31496677?dopt=Abstract Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease. Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2019;14:1779-1787 Authors: Mkorombindo T, Dransfield MT Abstract Despite maximal medical therapy, a subset of patients with chronic obstructive pulmonary disease continue to suffer acute exacerbations. It is […]
Personalized medicine for patients with COPD: where are we?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636434/ https://www.ncbi.nlm.nih.gov/pubmed/31371934?dopt=Abstract Personalized medicine for patients with COPD: where are we? Related Articles Personalized medicine for patients with COPD: where are we? Int J Chron Obstruct Pulmon Dis. 2019;14:1465-1484 Authors: Franssen FM, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EF, Schmeck B Abstract […]
Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo
http://www.clinsci.org/content/early/2019/07/03/CS20190331 https://www.ncbi.nlm.nih.gov/pubmed/31270147?dopt=Abstract Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo. Related Articles Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo. Clin Sci (Lond). 2019 Jul 03;: Authors: Sun X, Feng X, Zheng D, Li A, […]
Chemokines in COPD: From Implication to Therapeutic Use
https://www.mdpi.com/1422-0067/20/11/2785 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600384/ https://www.ncbi.nlm.nih.gov/pubmed/31174392?dopt=Abstract Chemokines in COPD: From Implication to Therapeutic Use. Related Articles Chemokines in COPD: From Implication to Therapeutic Use. Int J Mol Sci. 2019 Jun 06;20(11): Authors: Henrot P, Prevel R, Berger P, Dupin I Abstract : Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death in the world. The […]
12-month randomised controlled trial of ginseng extract for moderate COPD: no significant differences between ginseng and placebo
https://thorax.bmj.com/content/74/6/539 https://www.ncbi.nlm.nih.gov/pubmed/30940771?dopt=Abstract 12-month randomised controlled trial of ginseng extract for moderate COPD. Related Articles 12-month randomised controlled trial of ginseng extract for moderate COPD. Thorax. 2019 06;74(6):539-545 Authors: Shergis JL, Thien F, Worsnop CJ, Lin L, Zhang AL, Wu L, Chen Y, Xu Y, Langton D, Da Costa C, Fong H, Wu D, Story D, […]
MicroRNAs in COPD: small molecules with big potential
https://erj.ersjournals.com/content/53/4/1900515 https://www.ncbi.nlm.nih.gov/pubmed/31023868?dopt=Abstract MicroRNAs in COPD: small molecules with big potential. Related Articles MicroRNAs in COPD: small molecules with big potential. Eur Respir J. 2019 Apr;53(4): Authors: Hobbs BD, Tantisira KG PMID: 31023868 [PubMed – indexed for MEDLINE] PubMed:31023868 Hobbs BD, Tantisira KG
Macrolides for treatment of chronic obstructive pulmonary disease
https://journals.lww.com/cmj/Citation/publishahead/Macrolides_for_treatment_of_chronic_obstructive.99830.aspx https://www.ncbi.nlm.nih.gov/pubmed/30973449?dopt=Abstract Macrolides for treatment of chronic obstructive pulmonary disease. Macrolides for treatment of chronic obstructive pulmonary disease. Chin Med J (Engl). 2019 Apr 03;: Authors: Sun XJ, He ZY PMID: 30973449 [PubMed – as supplied by publisher] PubMed:30973449 Sun XJ, He ZY
Vitamin D reduces the serum levels of inflammatory cytokines in rat models of chronic obstructive pulmonary disease – “findings suggest that vitamin D supplementation could be a new clinical approach for the treatment of COPD”
https://www.jstage.jst.go.jp/article/josnusd/61/1/61_17-0357/_article https://www.ncbi.nlm.nih.gov/pubmed/30918217?dopt=Abstract Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. J Oral Sci. 2019;61(1):53-60 Authors: Han J, Cheng C, Zhu Z, Lin M, Zhang DX, […]
Genetic Advances in Chronic Obstructive Pulmonary Disease: Insights from COPDGene
https://www.atsjournals.org/doi/10.1164/rccm.201808-1455SO https://www.ncbi.nlm.nih.gov/pubmed/30908940 Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene Margaret F. Ragland 1*, Christopher J. Benway 2*, Sharon M. Lutz 3, Russell P. Bowler 4, Julian Hecker 5, John E. Hokanson 6, James D. Crapo 4, Peter J. Castaldi 2, Dawn L. DeMeo 2,7, Craig P. Hersh 2,7, Brian D. Hobbs 2,7, […]
Can treating vitamin D deficiency reduce exacerbations of chronic obstructive pulmonary disease?
https://www.bmj.com/content/364/bmj.l1025
Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease
https://erj.ersjournals.com/content/early/2019/01/30/13993003.01202-2018 https://www.ncbi.nlm.nih.gov/pubmed/30846474?dopt=Abstract Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. Related Articles Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. Eur Respir J. 2019 Mar 07;: Authors: Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, […]
Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012930.pub2/full https://www.ncbi.nlm.nih.gov/pubmed/30839102?dopt=Abstract Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019 Mar 06;3:CD012930 Authors: Maqsood U, Ho TN, Palmer K, Eccles […]
Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease
Based on GLP-1, it is proposed to create a drug to stimulate the regeneration of endothelium damaged in MS and COPD. https://www.mdpi.com/1422-0067/20/5/1105 https://www.ncbi.nlm.nih.gov/pubmed/30836679?dopt=Abstract Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease. Related Articles Endothelial Progenitor Cells as Pathogenetic and Diagnostic […]
Inflammatory endotypes in COPD
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13760 https://www.ncbi.nlm.nih.gov/pubmed/30834543?dopt=Abstract Inflammatory endotypes in COPD. Related Articles Inflammatory endotypes in COPD. Allergy. 2019 07;74(7):1249-1256 Authors: Barnes PJ Abstract Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat the underlying inflammation, which is largely corticosteroid-resistant in most patients. Although […]
Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA
https://www.ncbi.nlm.nih.gov/pubmed/30880943?dopt=Abstract Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA. Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA. Int J Chron Obstruct Pulmon Dis. 2019;14:531-546 Authors: Singh D, Fabbri LM, Vezzoli S, Petruzzelli S, Papi A Abstract Background: Current pharmacological therapies for COPD improve quality of […]
PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease
https://www.ncbi.nlm.nih.gov/pubmed/30827233?dopt=Abstract PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease. Related Articles PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease. Curr Drug Metab. 2019 Feb 27;: Authors: Sun X, Chen L, He Z Abstract BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a systematic inflammatory disease, and smoking is an important […]
Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease
https://www.ncbi.nlm.nih.gov/pubmed/30806122?dopt=Abstract Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease in the elderly. Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease in the elderly. Postgrad Med. 2019 Feb 26;: Authors: Qin J, Deng X, Wei A, Qin Y, Wu Y, Liao L, Lin F Abstract INTRODUCTION: Acute exacerbation of chronic […]
Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies
https://www.ncbi.nlm.nih.gov/pubmed/30822464?dopt=Abstract Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pharmacol Ther. 2019 Feb 26;: Authors: Chan SMH, Selemidis S, Bozinovski S, Vlahos R Abstract Chronic obstructive pulmonary disease (COPD) […]
Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol
https://www.ncbi.nlm.nih.gov/pubmed/30777117?dopt=Abstract Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol for a randomized controlled trial. Related Articles Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol for a randomized controlled trial. […]
Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6274 https://www.ncbi.nlm.nih.gov/pubmed/30701599?dopt=Abstract Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice. Related Articles Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice. Phytother Res. 2019 Jan 30;: Authors: Wang Z, Fang K, Wang G, Guan X, Pang Z, Guo Y, Yuan Y, Ran N, Liu […]
Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach
https://www.mdpi.com/1422-0067/20/3/553 https://www.ncbi.nlm.nih.gov/pubmed/30696075?dopt=Abstract Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach. Related Articles Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach. Int J Mol Sci. 2019 Jan 28;20(3): Authors: Tsai MJ, Tsai YC, Chang […]
Notch promotes DNMT-mediated hypermethylation of Klotho leads to COPD-related inflammation
https://www.tandfonline.com/doi/abs/10.1080/01902148.2018.1556749?journalCode=ielu20 https://www.ncbi.nlm.nih.gov/pubmed/30686068?dopt=Abstract
Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease
The role of LL-37 as a target for treatment of the immune system and COPD must be widely evaluated. https://www.dovepress.com/evaluation-of-plasma-antimicrobial-peptide-ll-37-and-nuclear-factor-ka-peer-reviewed-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/30774329?dopt=Abstract
Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs)
https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01520 https://www.ncbi.nlm.nih.gov/pubmed/30682248?dopt=Abstract Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). Related Articles Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jan 25;: Authors: Ti H, Zhou Y, Liang X, Li R, Ding K, Zhao X Abstract Chronic obstructive pulmonary disease (COPD) is a […]
Introduction to Precision Medicine in COPD
https://erj.ersjournals.com/content/early/2019/01/16/13993003.02460-2018 https://www.ncbi.nlm.nih.gov/pubmed/30679189?dopt=Abstract
Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance
https://www.hindawi.com/journals/ecam/2019/6471815/ https://www.ncbi.nlm.nih.gov/pubmed/30800170?dopt=Abstract
Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells
https://www.ncbi.nlm.nih.gov/pubmed/30651831?dopt=Abstract Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells. Related Articles Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells. Exp Ther Med. 2019 Jan;17(1):519-524 Authors: Wang L, Gu W, Shi Y, Chen Y, Tan Y Abstract The diaphragmatic fatigue that results from airflow obstruction is associated with the severe morbidity of […]
Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells
https://www.ncbi.nlm.nih.gov/pubmed/30654796?dopt=Abstract Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Related Articles Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Respir Res. 2019 Jan 17;20(1):11 Authors: Kubo F, […]
The COPD Pipeline 40
https://www.ncbi.nlm.nih.gov/pubmed/30775429?dopt=Abstract
Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway
https://www.sciencedirect.com/science/article/pii/S0006291X18328146?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30654931?dopt=Abstract Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway. Related Articles Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway. Biochem Biophys Res Commun. 2019 Jan 14;: Authors: Shen J, Nie X, Huang SY, Qin YQ, Pan LL, Wang XT Abstract Previous work […]
Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial
https://www.atsjournals.org/doi/10.1164/rccm.201805-0995OC https://www.ncbi.nlm.nih.gov/pubmed/30641027?dopt=Abstract Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial. Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial. Am J Respir Crit Care Med. 2019 Jan 14;: Authors: Vogel-Claussen J, Schönfeld CO, Kaireit TF, Voskrebenzev […]
Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice
https://www.physiology.org/doi/abs/10.1152/ajplung.00409.2018 https://www.ncbi.nlm.nih.gov/pubmed/30628489?dopt=Abstract Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 10;: Authors: Koike K, Beatman EL, Schweitzer KS, Justice MJ, […]
Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model
https://www.sciencedirect.com/science/article/pii/S0891584918317489?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30639616?dopt=Abstract Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model. Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model. Free Radic Biol Med. 2019 Jan 09;: Authors: Wang M, Zhang Y, Xu M, Zhang H, Chen Y, Chung KF, Adcock IM, Li F Abstract […]
miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5
https://www.sciencedirect.com/science/article/pii/S0009279718309311?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30639269?dopt=Abstract miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. Chem Biol Interact. 2019 Jan 08;: Authors: Dang X, Yang L, Guo J, Hu H, Li F, Liu Y, Pang Y Abstract Increasing evidence illustrate that dysregulation of microRNAs […]
Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases
https://www.sciencedirect.com/science/article/abs/pii/S0003986118306891?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30629957?dopt=Abstract Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases. Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases. Arch Biochem Biophys. 2019 Jan 07;: Authors: Pan S, Conaway S, Deshpande DA Abstract Mitochondria are important for airway smooth muscle physiology due to their diverse yet interconnected roles […]
DNA repair as an emerging target for COPD-lung cancer overlap
https://www.sciencedirect.com/science/article/pii/S2212534518301187?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30630751?dopt=Abstract DNA repair as an emerging target for COPD-lung cancer overlap. Related Articles DNA repair as an emerging target for COPD-lung cancer overlap. Respir Investig. 2019 Jan 07;: Authors: Sears CR Abstract Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette […]
Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease
https://www.ncbi.nlm.nih.gov/pubmed/30614746?dopt=Abstract Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. J Med Food. 2019 Jan 07;: Authors: Yang WK, Kim SH, Jung IC, Park YC Abstract […]
Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD)
https://www.sciencedirect.com/science/article/abs/pii/S0939641118309421?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30615927?dopt=Abstract Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Jan 04;: Authors: Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY Abstract RNA interference (RNAi) based therapeutics are […]
A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0963-0 https://www.ncbi.nlm.nih.gov/pubmed/30606200?dopt=Abstract A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation. Related Articles A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation. Respir Res. 2019 Jan 03;20(1):2 Authors: Morichika D, Miyahara N, Fujii U, Taniguchi A, Oda N, Senoo S, Kataoka M, Tanimoto M, Kakuta H, Kiura K, Maeda […]
Updated guidelines for chronic obstructive pulmonary disease.
https://www.ncbi.nlm.nih.gov/pubmed/30589738?dopt=Abstract Updated guidelines for chronic obstructive pulmonary disease. Related Articles Updated guidelines for chronic obstructive pulmonary disease. JAAPA. 2019 Jan;32(1):49-51 Authors: Dunn B Abstract The 2017 Global Initiative for Chronic Obstructive Lung Disease guidelines for the evaluation and management of chronic obstructive pulmonary disease revise the assessment tool used to evaluate patients, implement a new […]
Electroacupuncture Improves Pulmonary Function of Rats with Chronic Obstructive Pulmonary Disease by Down-regulating Inflammatory Reaction and Expression of Macrophage Migration Inhibitory Factor/CD 74-CD 44/p 38 MAPK Signaling in Lung Tissues
https://www.ncbi.nlm.nih.gov/pubmed/30585452 [Electroacupuncture Improves Pulmonary Function of Rats with Chronic Obstructive Pulmonary Disease by Down-regulating Inflammatory Reaction and Expression of Macrophage Migration Inhibitory Factor/CD 74-CD 44/p 38 MAPK Signaling in Lung Tissues].
Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB
https://www.ncbi.nlm.nih.gov/pubmed/30609878?dopt=Abstract Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB. Related Articles Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB. J Microbiol Biotechnol. 2018 Dec 24;: Authors: Liu J, Yao J, Zhang J Abstract […]
