This page keeps track of new/upcoming treatment options for chronic obstructive pulmonary disease (COPD). What’s in development? What’s promising? What’s available soon? Find out below… Current topics include CHF6523, MS1819, PT010, MPH966, MUC5AC, gene therapy, MEDI3506, stem cells, PDE3/4 inhibitors, ensifentrine, RPL554, BLT1 antagonists, BCT-197 (acumapimod), Kv11.1 channel blockers, SRT2104, and more.
Last updated: 3 years ago
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News
- Synairgen announces positive data from interim analysis of SNG001 trial in COPD patients Sep 8, 2020
- Drug development for severe respiratory diseases supported with $3.9 million grant: New drug candidate targets asthma, COPD, other progressive lung diseases Aug 12, 2020
- AstraZeneca Wins FDA Approval for COPD Treatment Jul 24, 2020
- Verona Pharma Raises $200 Million to support Phase 3 ENHANCE clinical program in COPD Jul 17, 2020
- Twice-daily Budesonide/Glycopyrrolate/Formoterol Significantly Lowered Exacerbations in Patients with Moderate or Severe COPD Jun 24, 2020
- Lung Denervation System Named FDA Breakthrough Device Jun 16, 2020
- Nuvaira Announces FDA Breakthrough Designation for AIRFLOW-3 Pivotal Trial Device Jun 8, 2020
- A New Report Confirms Significant Benefits in Patient Reported Outcomes at One Year Following the Non-Surgical Zephyr Valve Procedure for COPD/Emphysema May 12, 2020
- Lung Volume Reduction Coil Treatment Enables Recovery in Severe COPD Cases Mar 11, 2020
- Inhalation therapy shows promise against pulmonary fibrosis in mice, rats Feb 28, 2020
- Verona Pharma announces publication of Phase 2b clinical trial results for ensifentrine, a maintenance treatment for chronic obstructive pulmonary disease (COPD) Feb 14, 2020
- New hope for COPD patients possible with in-home device Feb 4, 2020
- Verona Pharma Reports Positive Top-line Data in Phase 2b COPD Study with Nebulized Ensifentrine on Top of Tiotropium Therapy Jan 13, 2020
- Cancer drugs could potentially treat COPD Jan 6, 2020
- Antiarrhythmic drug could also treat PAH, COPD Dec 16, 2019
- There’s now a life-changing treatment (Zephyr valve system) for COPD patients in Georgia Dec 15, 2019
- New Research Gives Hope for Slowing Progression and Mortality of Chronic Obstructive Pulmonary Disease (COPD) Nov 13, 2019
- COPD Foundation: COPD Awareness Month is Here! Nov 1, 2019
- Oscillating Vest Keeps COPD Patients Out of Hospital: Exacerbations reduced with technology initially designed for use in CF Oct 23, 2019
- Temple AIRFLOW-3 trial offers new approach to treating COPD Oct 22, 2019
- Verona Pharma Completes Enrollment in Phase 2b Clinical Trial for Ensifentrine in moderate-to-severe COPD Oct 17, 2019
- Bayer Will Invest $30M in Joint Research Lab for COPD, Other Chronic Lung Diseases Oct 15, 2019
- Verona Pharma to Present Phase 2 Symptom Data with Ensifentrine (RPL554) in COPD at CHEST 2019 Oct 15, 2019
- AzurRx BioPharma Announces Positive Results from Phase 2 Trial with MS1819 in Cystic Fibrosis Patients Sep 25, 2019
- AstraZeneca to present next wave of science in respiratory disease at ERS International Congress Sep 25, 2019
- PT010 Phase III ETHOS Trial Met Its Primary Endpoint in COPD Aug 29, 2019
- Circassia Pharma Receives 2nd FDA Approval for COPD Treatment in 2 Weeks Apr 18, 2019
- Circassia Announces FDA Approval of Duaklir for Maintenance Treatment of Chronic Obstructive Pulmonary Disease Apr 1, 2019
- AI-powered digital treatment can aid COPD treatment: Study Mar 9, 2019
- Queen’s Researchers make breakthrough in chronic lung disease Mar 7, 2019
- Verona announces positive results from Phase II COPD trial Mar 5, 2019
- WebMD: Daily Aspirin Might Ease COPD Flare-Ups Mar 4, 2019
- Nuvaira Raises $79M for COPD Treatment Device Feb 11, 2019
- New COPD treatment at UofL Hospital is a ‘landmark development’ Feb 6, 2019
- Researchers breathe new life into COPD research using mouse models Jan 31, 2019
- FDA Approves Generic Inhalation Treatment for Asthma, COPD Jan 30, 2019
- FDA approves first generic Advair Diskus Jan 30, 2019
- Inhalable MRNA: New Delivery Method Could Help Treat Patients Of Lung Disease Jan 11, 2019
- New Shock Treatment Showing Promise For COPD Patients Jan 7, 2019
- Engineers create an inhalable form of messenger RNA Jan 4, 2019
- Teva’s ProAir Digihaler FDA Approved to Monitor Asthma and COPD Treatment Dec 26, 2018
- Synairgen Developing COPD Treatment To Hold Off Further Viral Damage Dec 18, 2018
- Zapping airway nerves may help COPD patients breathe Nov 29, 2018
- FDA Approves Revefenacin, a Once-a-Day Nebulized LAMA, for COPD Nov 9, 2018
- Theravance Biopharma and Mylan Receive FDA Approval for YUPELRI™ (revefenacin) in Adults with Chronic Obstructive Pulmonary Disease Nov 9, 2018
- Zapping Airway Nerves May Help COPD Patients Sep 18, 2018
- Testosterone replacement therapy could slow the progression of COPD Sep 18, 2018
- FDA-Approved Valve Treatment For COPD Seeing Positive Results Jul 24, 2018
- FDA approves novel device for treating breathing difficulty from severe emphysema Jun 29, 2018
Research
- Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator Sep 9, 2020
- Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial Aug 13, 2020
- Biomarkers in Chronic Obstructive Pulmonary Disease: The Gateway to Precision Medicine Aug 12, 2020
- The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease Aug 11, 2020
- Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease. Aug 11, 2020
- Preventive and therapeutic effectiveness of Sanfu acupoint herbal patching for chronic obstructive pulmonary disease at stable stages: a systematic review and meta-analysis Aug 4, 2020
- Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy Jul 29, 2020
- Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence Jul 28, 2020
- Difference in the metabolic characteristics of chronic obstructive pulmonary disease patients and healthy adults Jul 24, 2020
- ADAM15 deficiency increased pulmonary inflammation in mice and is strongly linked to the pathogenesis of COPD Jul 20, 2020
- Fecal microbial transplantation (FMT) and a high fiber diet (HFD) attenuates emphysema development by suppressing inflammation and apoptosis Jul 17, 2020
- ADAM15 expression is increased in lung CD8+ T cells, macrophages, and bronchial epithelial cells in patients with COPD and is inversely related to airflow obstruction Jul 16, 2020
- Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease Jul 15, 2020
- Vitamin B12 Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study Jul 14, 2020
- PR1P as a novel therapeutic agent for the treatment of emphysema or other lung diseases characterized by VEGF signaling dysregulation Jul 14, 2020
- Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD Jul 2, 2020
- Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis Jul 2, 2020
- The Role of Toll-Like Receptors 2 (TLR2) and 4 (TLR4) in the Pathogenesis of Chronic Obstructive Pulmonary Disease Jun 23, 2020
- The Adjunctive Effect of Intravenous Magnesium Sulfate in Acute Exacerbation of COPD Jun 15, 2020
- CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial Jun 12, 2020
- NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD Jun 8, 2020
- Effects of compound Caoshi silkworm granules (CCSGs) on stable COPD patients and their relationship with gut microbiota May 29, 2020
- The Relevance of Targeting Treatment to Small Airways in Asthma and COPD: the newest technological therapeutic advances Mar 24, 2020
- Hesperidin alleviated inflammation and oxidative stress responses in COPD mice, associated with SIRT1/PGC-1α/NF-κB signaling axis: a new direction for COPD treatment Mar 13, 2020
- The Efficacy of Lung Volume Reduction Coil Treatment in Patients with Severe Chronic Obstructive Pulmonary Disease (COPD) Type II Respiratory Failure Mar 3, 2020
- The key role of macrophage depolarization in the treatment of COPD with ergosterol Dec 20, 2019
- Bu-Shen-Fang-Chuan formula (BSFCF) attenuates T-lymphocytes recruitment and improves pulmonary function in rat model of COPD through suppressing CXCL9/CXCL10/CXCL11-CXCR3 axis Dec 17, 2019
- Oral formulation angiotensin-(1-7) therapy attenuates pulmonary and systemics damage in mice with emphysema Dec 4, 2019
- Dynamic changes of gut and lung microorganisms during chronic obstructive pulmonary disease exacerbations: possibly a target for future therapeutics Nov 29, 2019
- Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol Nov 28, 2019
- Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD Nov 26, 2019
- Role of melatonin as an SIRT1 enhancer in chronic obstructive pulmonary disease induced by cigarette smoke Nov 25, 2019
- LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD Nov 22, 2019
- Chronic obstructive pulmonary disease and phenotypes: a state-of-the-art [Review] Nov 15, 2019
- Acumapimod (BCT197) to Treat Acute Exacerbations of COPD Nov 4, 2019
- Inhibitors of ErbB kinases have therapeutic potential in neutrophilic inflammatory diseases, including chronic obstructive pulmonary disease (COPD) Oct 15, 2019
- Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease Oct 11, 2019
- Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases Oct 10, 2019
- Lipids in COPD: A Target for Future Therapy? [PDF] Oct 2, 2019
- Allyl isothiocyanate (AITC) may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway Sep 30, 2019
- Therapeutic efficacy of the aqueous extract of the stem bark of Ximenia americana L. in the treatment of experimental COPD in rats Sep 29, 2019
- DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough Sep 27, 2019
- COPD: preclinical models and emerging therapeutic targets Sep 20, 2019
- Dissection of Pharmacological Mechanism of Chinese Herbal Medicine Yihuo Huatan Formula on Chronic Obstructive Pulmonary Disease Sep 17, 2019
- Carbocisteine inhibits the expression of Muc5b in COPD mouse model Sep 16, 2019
- Anti-viral immunity is impaired in COPD patients with frequent exacerbations Sep 12, 2019
- Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model Sep 12, 2019
- miRNA‑101‑3p.1 facilitates COPD progression by activating the EGFR/PI3K/AKT signaling pathway Sep 9, 2019
- Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation Sep 4, 2019
- Immune-Modulation in Chronic Obstructive Pulmonary Disease: Current Concepts and Future Strategies Sep 3, 2019
- Ensifentrine (RPL554): an investigational PDE3/4 inhibitor for the treatment of COPD Sep 1, 2019
- Pharmacological treatment and current controversies in COPD Aug 29, 2019
- Efficacy and safety of inhaled alpha-1-antitrypsin in severe COPD patients with alpha-1-antitrypsin deficiency Aug 29, 2019
- CARM1 contributes to airway repair and regeneration by regulating airway epithelial cell senescence Aug 28, 2019
- Wharton’s jelly-derived mesenchymal stem cells show pulmonary regenerative effects in COPD mouse model Aug 24, 2019
- Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease Aug 7, 2019
- Personalized medicine for patients with COPD: where are we? Jul 9, 2019
- Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo Jul 3, 2019
- Chemokines in COPD: From Implication to Therapeutic Use Jun 6, 2019
- 12-month randomised controlled trial of ginseng extract for moderate COPD: no significant differences between ginseng and placebo May 15, 2019
- MicroRNAs in COPD: small molecules with big potential Apr 25, 2019
- Macrolides for treatment of chronic obstructive pulmonary disease Apr 3, 2019
- Vitamin D reduces the serum levels of inflammatory cytokines in rat models of chronic obstructive pulmonary disease – “findings suggest that vitamin D supplementation could be a new clinical approach for the treatment of COPD” Mar 29, 2019
- Genetic Advances in Chronic Obstructive Pulmonary Disease: Insights from COPDGene Mar 20, 2019
- Can treating vitamin D deficiency reduce exacerbations of chronic obstructive pulmonary disease? Mar 18, 2019
- Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease Mar 7, 2019
- Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease Mar 6, 2019
- Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease Mar 4, 2019
- Inflammatory endotypes in COPD Mar 4, 2019
- Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA Feb 28, 2019
- PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease Feb 27, 2019
- Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease Feb 26, 2019
- Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies Feb 26, 2019
- Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol Feb 18, 2019
- Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice Jan 30, 2019
- Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach Jan 28, 2019
- Notch promotes DNMT-mediated hypermethylation of Klotho leads to COPD-related inflammation Jan 26, 2019
- Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease Jan 25, 2019
- Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs) Jan 25, 2019
- Introduction to Precision Medicine in COPD Jan 24, 2019
- Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance Jan 20, 2019
- Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells Jan 17, 2019
- Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells Jan 17, 2019
- The COPD Pipeline 40 Jan 14, 2019
- Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway Jan 14, 2019
- Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial Jan 14, 2019
- Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice Jan 10, 2019
- Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model Jan 9, 2019
- miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5 Jan 9, 2019
- Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases Jan 8, 2019
- DNA repair as an emerging target for COPD-lung cancer overlap Jan 7, 2019
- Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease Jan 7, 2019
- Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD) Jan 4, 2019
- A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation Jan 3, 2019
- Updated guidelines for chronic obstructive pulmonary disease. Dec 29, 2018
- Electroacupuncture Improves Pulmonary Function of Rats with Chronic Obstructive Pulmonary Disease by Down-regulating Inflammatory Reaction and Expression of Macrophage Migration Inhibitory Factor/CD 74-CD 44/p 38 MAPK Signaling in Lung Tissues Dec 25, 2018
- Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB Dec 24, 2018
- Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease Dec 21, 2018
- Advancing COPD Therapy: Opportunities, Challenges and Excitement Dec 18, 2018
- Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD) Dec 11, 2018
- Cell-based Therapy for Chronic Obstructive Pulmonary Disease. Rebuilding the Lung Dec 1, 2018
- Traditional Chinese medicine tonifying kidney therapy (Bu shen) for stable chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis Dec 1, 2018
- Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS Nov 26, 2018
- The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3 inflammasome activation and ROS production Aug 10, 2018
- Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema Aug 8, 2018
- Endobronchial coil therapy in severe emphysema: 6-month outcomes from a Swiss National Registry Aug 1, 2018
- Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice Jun 29, 2018
- Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study May 16, 2018
- MyD88 as a therapeutic target for inflammatory lung diseases Apr 20, 2018
Clinical Trials
- Dose-range Finding Efficacy and Safety Study for QBW251 in COPD Patients Jul 29, 2020
- Fiber Metabolism in Chronic Obstructive Pulmonary Disease Jul 7, 2020
- Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab (SAR231893) in Patients With Moderate to Severe COPD With Type 2 Inflammation Jul 2, 2020
- A Study of RPL554 Drug Administered by Metered Dose Inhaler to Treat Chronic Obstructive Pulmonary Disease Feb 24, 2020
- The Safety and Feasibility of UMC119-06 Cell Therapy (Mesenchymal Stem Cells) in Subjects With Chronic Obstructive Pulmonary Disease Dec 20, 2019
- Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD) Dec 12, 2019
- The Use of Benralizumab, an Interleukin-5 Receptor-α Monoclonal Antibody as Treatment of Acute Exacerbations of Airways Disease Sep 23, 2019
- Study to evaluate the impact of inhaled PT003 in moderate to severe COPD patients Sep 12, 2019
- Investigate the Safety, Tolerability and Pharmacokinetics of CHF6523 in Healthy and in COPD Subjects Aug 1, 2019
- Photobiomodulation in Individuals With Chronic Obstructive Pulmonary Disease Jul 8, 2019
- The Effectiveness of Bottle-PEP in Chronic Obstructive Pulmonary Disease Apr 2, 2019
- The Effect of FP-025, a MMP-12 Inhibitor, on Airway Responses and Airway Inflammation Mar 1, 2019
- The Effects of RPL554 in Addition to Tiotropium in COPD Patients [Completed] Feb 27, 2019
- Arbidol for COPD Exacerbations Feb 22, 2019
- A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia Jan 18, 2019
- Safety and Tolerability of MEDI3506 in Healthy Subjects, in Subjects With COPD and Healthy Japanese Subjects Jan 8, 2019
- A Study to Test a Potential New Treatment for COPD Patients Suffering From the Common Cold or Influenza Dec 31, 2018
- A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD) Dec 31, 2018
- Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD) Dec 31, 2018
- Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients Dec 25, 2018
- Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency Dec 18, 2018
- A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases Dec 8, 2018
- A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo Nov 15, 2018
- Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract Nov 15, 2018
- Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Nov 14, 2018
- Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells In Chronic Lung Disorders Nov 8, 2018
- A Study to Assess the Efficacy of a 5-day, 10- mg PBF-680 Oral Administration on Late Asthmatic Responses (LAR) in Mild to Moderate Asthmatic Patients Nov 6, 2018
- Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD Nov 4, 2018
- Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP) Oct 31, 2018
- A Pilot Study of the Use of Metformin to Reduce Airway Glucose in COPD Aug 29, 2018