Circassia Announces FDA Approval of Duaklir® for Maintenance Treatment of Chronic Obstructive Pulmonary Disease
Vitamin D reduces the serum levels of inflammatory cytokines in rat models of chronic obstructive pulmonary disease – “findings suggest that vitamin D supplementation could be a new clinical approach for the treatment of COPD”
https://www.jstage.jst.go.jp/article/josnusd/61/1/61_17-0357/_article https://www.ncbi.nlm.nih.gov/pubmed/30918217?dopt=Abstract Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease. J Oral Sci. 2019;61(1):53-60 Authors: Han J, Cheng C, Zhu Z, Lin M, Zhang DX, […]
Genetic Advances in Chronic Obstructive Pulmonary Disease: Insights from COPDGene
https://www.atsjournals.org/doi/10.1164/rccm.201808-1455SO https://www.ncbi.nlm.nih.gov/pubmed/30908940 Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene Margaret F. Ragland 1*, Christopher J. Benway 2*, Sharon M. Lutz 3, Russell P. Bowler 4, Julian Hecker 5, John E. Hokanson 6, James D. Crapo 4, Peter J. Castaldi 2, Dawn L. DeMeo 2,7, Craig P. Hersh 2,7, Brian D. Hobbs 2,7, […]
Can treating vitamin D deficiency reduce exacerbations of chronic obstructive pulmonary disease?
https://www.bmj.com/content/364/bmj.l1025
AI-powered digital treatment can aid COPD treatment: Study
http://www.digitaljournal.com/life/health/ai-powered-digital-treatment-can-aid-copd-treatment-study/article/544910
Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease
https://erj.ersjournals.com/content/early/2019/01/30/13993003.01202-2018 https://www.ncbi.nlm.nih.gov/pubmed/30846474?dopt=Abstract Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. Related Articles Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease. Eur Respir J. 2019 Mar 07;: Authors: Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, […]
Queen’s Researchers make breakthrough in chronic lung disease
https://www.qub.ac.uk/News/Allnews/QueensResearchersmakebreakthroughinchroniclungdisease.html
Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012930.pub2/full https://www.ncbi.nlm.nih.gov/pubmed/30839102?dopt=Abstract Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019 Mar 06;3:CD012930 Authors: Maqsood U, Ho TN, Palmer K, Eccles […]
Verona announces positive results from Phase II COPD trial
http://www.pharmatimes.com/news/verona_announces_positive_results_from_phase_ii_copd_trial_1280333
Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease
Based on GLP-1, it is proposed to create a drug to stimulate the regeneration of endothelium damaged in MS and COPD. https://www.mdpi.com/1422-0067/20/5/1105 https://www.ncbi.nlm.nih.gov/pubmed/30836679?dopt=Abstract Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease. Related Articles Endothelial Progenitor Cells as Pathogenetic and Diagnostic […]
WebMD: Daily Aspirin Might Ease COPD Flare-Ups
https://www.webmd.com/lung/copd/news/20190304/daily-aspirin-might-ease-copd-flare-ups
Inflammatory endotypes in COPD
https://onlinelibrary.wiley.com/doi/full/10.1111/all.13760 https://www.ncbi.nlm.nih.gov/pubmed/30834543?dopt=Abstract Inflammatory endotypes in COPD. Related Articles Inflammatory endotypes in COPD. Allergy. 2019 07;74(7):1249-1256 Authors: Barnes PJ Abstract Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat the underlying inflammation, which is largely corticosteroid-resistant in most patients. Although […]
The Effect of FP-025, a MMP-12 Inhibitor, on Airway Responses and Airway Inflammation
https://clinicaltrials.gov/ct2/show/NCT03858686?type=Intr&cond=COPD&phase=01234&lupd_s=02%2F15%2F2019&lupd_d=14&sort=nwst The Effect of FP-025, a MMP-12 Inhibitor, on Allergen-induced Airway Responses and Airway Inflammation in Mild Eosinophilic House Dust Mite (HDM)-Allergic Asthma Condition : Asthma, COPD Interventions : Drug: FP-025 capsules; Drug: Placebo FP-025 capsules Sponsor : Foresee Pharmaceuticals Co., Ltd. Recruiting NCT03858686 Fri, 01 Mar 2019 12:00:00 EST
Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA
https://www.ncbi.nlm.nih.gov/pubmed/30880943?dopt=Abstract Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA. Extrafine triple therapy delays COPD clinically important deterioration vs ICS/LABA, LAMA, or LABA/LAMA. Int J Chron Obstruct Pulmon Dis. 2019;14:531-546 Authors: Singh D, Fabbri LM, Vezzoli S, Petruzzelli S, Papi A Abstract Background: Current pharmacological therapies for COPD improve quality of […]
PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease
https://www.ncbi.nlm.nih.gov/pubmed/30827233?dopt=Abstract PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease. Related Articles PI3K/Akt-Nrf2 and Anti-Inflammation Effect of Macrolides in Chronic Obstructive Pulmonary Disease. Curr Drug Metab. 2019 Feb 27;: Authors: Sun X, Chen L, He Z Abstract BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a systematic inflammatory disease, and smoking is an important […]
The Effects of RPL554 in Addition to Tiotropium in COPD Patients [Completed]
https://clinicaltrials.gov/ct2/show/NCT03028142?type=Intr https://clinicaltrials.gov/ct2/show/NCT03028142?type=Intr&cond=COPD&phase=01234&lupd_s=01%2F09%2F2019&lupd_d=14&sort=nwst The Effects of RPL554 in Addition to Tiotropium in COPD Patients Condition : Chronic Obstructive Pulmonary Disease Moderate Interventions : Drug: 1.5 mg RPL554 plus tiotropium; Drug: 6 mg RPL554 plus tiotropium; Drug: Placebo plus tiotropium Sponsor : Verona Pharma plc Completed NCT03028142 Mon, 23 Jan 2017 12:00:00 EST
Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease
https://www.ncbi.nlm.nih.gov/pubmed/30806122?dopt=Abstract Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease in the elderly. Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease in the elderly. Postgrad Med. 2019 Feb 26;: Authors: Qin J, Deng X, Wei A, Qin Y, Wu Y, Liao L, Lin F Abstract INTRODUCTION: Acute exacerbation of chronic […]
Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies
https://www.ncbi.nlm.nih.gov/pubmed/30822464?dopt=Abstract Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pharmacol Ther. 2019 Feb 26;: Authors: Chan SMH, Selemidis S, Bozinovski S, Vlahos R Abstract Chronic obstructive pulmonary disease (COPD) […]
Arbidol for COPD Exacerbations
https://clinicaltrials.gov/ct2/show/NCT03851991?type=Intr&cond=COPD&phase=01234&lupd_s=02%2F08%2F2019&lupd_d=14&sort=nwst Arbidol for COPD Exacerbations Condition : COPD Patients Interventions : Drug: Arbidol; Drug: Placebos Sponsor : Shengjing Hospital Not yet recruiting NCT03851991 Fri, 22 Feb 2019 12:00:00 EST Last Update Posted: 26 Feb 2019
Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol
https://www.ncbi.nlm.nih.gov/pubmed/30777117?dopt=Abstract Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol for a randomized controlled trial. Related Articles Efficacy and safety of Xuebijing injection and its influence on immunomodulation in acute exacerbations of chronic obstructive pulmonary disease: study protocol for a randomized controlled trial. […]
Nuvaira Raises $79M for COPD Treatment Device
https://www.mddionline.com/nuvaira-raises-79m-copd-treatment-device
New COPD treatment at UofL Hospital is a ‘landmark development’
https://www.whas11.com/article/news/new-copd-treatment-at-uofl-hospital-is-a-landmark-development/417-0c0be1d0-5819-40bb-bb64-e4b433fd0b6f https://www.pulmonx.com/en/ous/professionals/products/zephyr-endobronchial-valve/
Researchers breathe new life into COPD research using mouse models
https://www.sciencedaily.com/releases/2019/01/190131113843.htm Researchers breathe new life into COPD research using mouse models Date: January 31, 2019 Source: Tokyo Medical and Dental University Summary: Researchers revealed that the immune cells basophils caused emphysema in mice with COPD-like features induced by intranasal administration of elastase. They showed that basophils, previously linked mainly to allergies and fighting parasites, initiated […]
Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6274 https://www.ncbi.nlm.nih.gov/pubmed/30701599?dopt=Abstract Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice. Related Articles Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice. Phytother Res. 2019 Jan 30;: Authors: Wang Z, Fang K, Wang G, Guan X, Pang Z, Guo Y, Yuan Y, Ran N, Liu […]
FDA Approves Generic Inhalation Treatment for Asthma, COPD
https://www.pharmacytimes.com/resource-centers/asthma/fda-approves-generic-inhalation-treatment-for-asthma-copd FDA Approves Generic Inhalation Treatment for Asthma, COPD
FDA approves first generic Advair Diskus
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm630151.htm FDA approves first generic Advair Diskus
Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach
https://www.mdpi.com/1422-0067/20/3/553 https://www.ncbi.nlm.nih.gov/pubmed/30696075?dopt=Abstract Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach. Related Articles Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach. Int J Mol Sci. 2019 Jan 28;20(3): Authors: Tsai MJ, Tsai YC, Chang […]
Notch promotes DNMT-mediated hypermethylation of Klotho leads to COPD-related inflammation
https://www.tandfonline.com/doi/abs/10.1080/01902148.2018.1556749?journalCode=ielu20 https://www.ncbi.nlm.nih.gov/pubmed/30686068?dopt=Abstract
Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease
The role of LL-37 as a target for treatment of the immune system and COPD must be widely evaluated. https://www.dovepress.com/evaluation-of-plasma-antimicrobial-peptide-ll-37-and-nuclear-factor-ka-peer-reviewed-article-COPD https://www.ncbi.nlm.nih.gov/pubmed/30774329?dopt=Abstract
Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs)
https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01520 https://www.ncbi.nlm.nih.gov/pubmed/30682248?dopt=Abstract Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). Related Articles Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jan 25;: Authors: Ti H, Zhou Y, Liang X, Li R, Ding K, Zhao X Abstract Chronic obstructive pulmonary disease (COPD) is a […]
Introduction to Precision Medicine in COPD
https://erj.ersjournals.com/content/early/2019/01/16/13993003.02460-2018 https://www.ncbi.nlm.nih.gov/pubmed/30679189?dopt=Abstract
Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance
https://www.hindawi.com/journals/ecam/2019/6471815/ https://www.ncbi.nlm.nih.gov/pubmed/30800170?dopt=Abstract
A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia
https://clinicaltrials.gov/ct2/show/NCT03810183?type=Intr&cond=COPD&phase=01234&lupd_s=01%2F04%2F2019&lupd_d=14&sort=nwst A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia Condition : COPD Interventions : Drug: QAW039; Drug: Placebo Sponsor : Novartis Pharmaceuticals Not yet recruiting NCT03810183 Fri, 18 Jan 2019 12:00:00 EST
Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells
https://www.ncbi.nlm.nih.gov/pubmed/30651831?dopt=Abstract Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells. Related Articles Protective effects of astragaloside IV on IL-8-treated diaphragmatic muscle cells. Exp Ther Med. 2019 Jan;17(1):519-524 Authors: Wang L, Gu W, Shi Y, Chen Y, Tan Y Abstract The diaphragmatic fatigue that results from airflow obstruction is associated with the severe morbidity of […]
Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells
https://www.ncbi.nlm.nih.gov/pubmed/30654796?dopt=Abstract Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Related Articles Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Respir Res. 2019 Jan 17;20(1):11 Authors: Kubo F, […]
The COPD Pipeline 40
https://www.ncbi.nlm.nih.gov/pubmed/30775429?dopt=Abstract
Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway
https://www.sciencedirect.com/science/article/pii/S0006291X18328146?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30654931?dopt=Abstract Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway. Related Articles Neuromuscular electrical stimulation improves muscle atrophy induced by chronic hypoxia-hypercapnia through the MicroRNA-486/PTEN/FoxO1 pathway. Biochem Biophys Res Commun. 2019 Jan 14;: Authors: Shen J, Nie X, Huang SY, Qin YQ, Pan LL, Wang XT Abstract Previous work […]
Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial
https://www.atsjournals.org/doi/10.1164/rccm.201805-0995OC https://www.ncbi.nlm.nih.gov/pubmed/30641027?dopt=Abstract Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial. Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated COPD Patients (CLAIM): A Double-Blind, Randomised, Crossover Trial. Am J Respir Crit Care Med. 2019 Jan 14;: Authors: Vogel-Claussen J, Schönfeld CO, Kaireit TF, Voskrebenzev […]
Inhalable MRNA: New Delivery Method Could Help Treat Patients Of Lung Disease
https://www.evolving-science.com/health/inhalable-mrna-00895 Inhalable MRNA: New Delivery Method Could Help Treat Patients Of Lung Disease
Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice
https://www.physiology.org/doi/abs/10.1152/ajplung.00409.2018 https://www.ncbi.nlm.nih.gov/pubmed/30628489?dopt=Abstract Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 10;: Authors: Koike K, Beatman EL, Schweitzer KS, Justice MJ, […]
Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model
https://www.sciencedirect.com/science/article/pii/S0891584918317489?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30639616?dopt=Abstract Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model. Roles of TRPA1 and TRPV1 in Cigarette Smoke -induced Airway Epithelial Cell Injury Model. Free Radic Biol Med. 2019 Jan 09;: Authors: Wang M, Zhang Y, Xu M, Zhang H, Chen Y, Chung KF, Adcock IM, Li F Abstract […]
miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5
https://www.sciencedirect.com/science/article/pii/S0009279718309311?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30639269?dopt=Abstract miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. Chem Biol Interact. 2019 Jan 08;: Authors: Dang X, Yang L, Guo J, Hu H, Li F, Liu Y, Pang Y Abstract Increasing evidence illustrate that dysregulation of microRNAs […]
Safety and Tolerability of MEDI3506 in Healthy Subjects, in Subjects With COPD and Healthy Japanese Subjects
https://clinicaltrials.gov/ct2/show/NCT03096795 Safety and Tolerability of MEDI3506 in Healthy Subjects, in Subjects With COPD and Healthy Japanese SubjectsClinicalTrials.gov Identifier: NCT03096795 Recruitment Status : Recruiting First Posted : March 30, 2017 Last Update Posted : January 8, 2019 See Contacts and Locations Sponsor: MedImmune LLC Information provided by (Responsible Party): MedImmune LLC Study Details Tabular ViewNo Results […]
Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases
https://www.sciencedirect.com/science/article/abs/pii/S0003986118306891?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30629957?dopt=Abstract Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases. Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases. Arch Biochem Biophys. 2019 Jan 07;: Authors: Pan S, Conaway S, Deshpande DA Abstract Mitochondria are important for airway smooth muscle physiology due to their diverse yet interconnected roles […]
New Shock Treatment Showing Promise For COPD Patients
New Shock Treatment Showing Promise For COPD Patients New Shock Treatment Showing Promise For COPD Patients
DNA repair as an emerging target for COPD-lung cancer overlap
https://www.sciencedirect.com/science/article/pii/S2212534518301187?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30630751?dopt=Abstract DNA repair as an emerging target for COPD-lung cancer overlap. Related Articles DNA repair as an emerging target for COPD-lung cancer overlap. Respir Investig. 2019 Jan 07;: Authors: Sears CR Abstract Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette […]
Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease
https://www.ncbi.nlm.nih.gov/pubmed/30614746?dopt=Abstract Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. J Med Food. 2019 Jan 07;: Authors: Yang WK, Kim SH, Jung IC, Park YC Abstract […]
Engineers create an inhalable form of messenger RNA
https://news.mit.edu/2019/inhalable-messenger-rna-lung-disease-0104 Engineers create an inhalable form of messenger RNA
Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD)
https://www.sciencedirect.com/science/article/abs/pii/S0939641118309421?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30615927?dopt=Abstract Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). Polymeric Nanoparticles for the Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). Eur J Pharm Biopharm. 2019 Jan 04;: Authors: Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY Abstract RNA interference (RNAi) based therapeutics are […]
A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0963-0 https://www.ncbi.nlm.nih.gov/pubmed/30606200?dopt=Abstract A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation. Related Articles A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation. Respir Res. 2019 Jan 03;20(1):2 Authors: Morichika D, Miyahara N, Fujii U, Taniguchi A, Oda N, Senoo S, Kataoka M, Tanimoto M, Kakuta H, Kiura K, Maeda […]
Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD)
https://clinicaltrials.gov/ct2/show/NCT02459080?type=Intr&cond=COPD&phase=01234&lupd_s=12%2F17%2F2018&lupd_d=14&sort=nwst Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD) Condition : Chronic Obstructive Pulmonary Disease (COPD) Interventions : Drug: TD-4208; Drug: Placebo Sponsor : Theravance Biopharma Completed NCT02459080 Mon, 01 Jun 2015 12:00:00 EDT
A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
https://clinicaltrials.gov/ct2/show/NCT02518139?type=Intr&cond=COPD&phase=01234&lupd_s=12%2F17%2F2018&lupd_d=14&sort=nwst A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD) Condition : Chronic Obstructive Pulmonary Disease (COPD) Interventions : Drug: TD-4208; Drug: Tiotropium Sponsor : Theravance Biopharma Completed NCT02518139 Fri, 07 Aug 2015 12:00:00 EDT
A Study to Test a Potential New Treatment for COPD Patients Suffering From the Common Cold or Influenza
https://clinicaltrials.gov/ct2/show/NCT03570359?type=Intr&cond=COPD&phase=01234&lupd_s=12%2F17%2F2018&lupd_d=14&sort=nwst A Study to Test a Potential New Treatment for COPD Patients Suffering From the Common Cold or Influenza Condition : Chronic Obstructive Pulmonary Disease (COPD) Interventions : Drug: Interferon Beta-1A; Other: Placebo Sponsor : Synairgen Research Ltd. Recruiting NCT03570359 Wed, 27 Jun 2018 12:00:00 EDT
Updated guidelines for chronic obstructive pulmonary disease.
https://www.ncbi.nlm.nih.gov/pubmed/30589738?dopt=Abstract Updated guidelines for chronic obstructive pulmonary disease. Related Articles Updated guidelines for chronic obstructive pulmonary disease. JAAPA. 2019 Jan;32(1):49-51 Authors: Dunn B Abstract The 2017 Global Initiative for Chronic Obstructive Lung Disease guidelines for the evaluation and management of chronic obstructive pulmonary disease revise the assessment tool used to evaluate patients, implement a new […]
Teva’s ProAir Digihaler FDA Approved to Monitor Asthma and COPD Treatment
Teva’s ProAir Digihaler FDA Approved to Monitor Asthma and COPD Treatment Teva’s ProAir Digihaler FDA Approved to Monitor Asthma and COPD Treatment
Electroacupuncture Improves Pulmonary Function of Rats with Chronic Obstructive Pulmonary Disease by Down-regulating Inflammatory Reaction and Expression of Macrophage Migration Inhibitory Factor/CD 74-CD 44/p 38 MAPK Signaling in Lung Tissues
https://www.ncbi.nlm.nih.gov/pubmed/30585452 [Electroacupuncture Improves Pulmonary Function of Rats with Chronic Obstructive Pulmonary Disease by Down-regulating Inflammatory Reaction and Expression of Macrophage Migration Inhibitory Factor/CD 74-CD 44/p 38 MAPK Signaling in Lung Tissues].
Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients
https://clinicaltrials.gov/ct2/show/NCT03781895?type=Intr&cond=COPD&phase=01234&sfpd_d=14&sort=nwst&sel_rss=new14 Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients Condition : Stable COPD Patients Intervention : Drug: Cholecalciferol Sponsor : Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Completed NCT03781895 Thu, 20 Dec 2018 12:00:00 EST >>> updated dec 25, completed
Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB
https://www.ncbi.nlm.nih.gov/pubmed/30609878?dopt=Abstract Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB. Related Articles Naringenin attenuates inflammation in chronic obstructive pulmonary disease in cigarette smoke induced mouse model and involves suppression of NF-κB. J Microbiol Biotechnol. 2018 Dec 24;: Authors: Liu J, Yao J, Zhang J Abstract […]
Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease
https://www.resmedjournal.com/article/S0954-6111(18)30396-2/fulltext https://linkinghub.elsevier.com/retrieve/pii/S0954611118303962 https://www.ncbi.nlm.nih.gov/pubmed/30665512?dopt=Abstract Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease. Related Articles Possible role of airway microvascular permeability on airway obstruction in patients with chronic obstructive pulmonary disease. Respir Med. 2019 Jan;146:137-141 Authors: Kyomoto Y, Kanazawa H, Tochino Y, Watanabe T, Asai K, Kawaguchi T Abstract […]
Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency
https://clinicaltrials.gov/ct2/show/NCT03679598?type=Intr&cond=COPD&phase=01234&lupd_s=12%2F13%2F2018&lupd_d=14&sort=nwst Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency Conditions : Alpha-1 Antitrypsin Deficiency (AATD); Pi*ZZ, Pi*SZ, or Pi*Null Phenotype; Emphysema or COPD Interventions : Drug: Alvelestat (MPH996); Other: Placebo Sponsors : University of Alabama at Birmingham; National Institutes of Health (NIH); Mereo BioPharma Not yet recruiting NCT03679598 Thu, 20 Sep 2018 12:00:00 EDT >>> updated dec 18, 2018
Advancing COPD Therapy: Opportunities, Challenges and Excitement
https://www.atsjournals.org/doi/10.1165/rcmb.2018-0288ED https://www.ncbi.nlm.nih.gov/pubmed/30562048 Am J Respir Cell Mol Biol. 2018 Dec 18. doi: 10.1165/rcmb.2018-0288ED. [Epub ahead of print] Advancing COPD Therapy: Opportunities, Challenges and Excitement. Advancing COPD Therapy: Opportunities, Challenges and Excitement NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys PubMed US National Library of Medicine National Institutes of […]
Synairgen Developing COPD Treatment To Hold Off Further Viral Damage
https://scrip.pharmaintelligence.informa.com/SC124368/Synairgen-Developing-COPD-Treatment-To-Hold-Off-Further-Viral-Damage Synairgen Developing COPD Treatment To Hold Off Further Viral Damage
Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD)
https://www.sciencedirect.com/science/article/pii/S0223523418310572?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30612088?dopt=Abstract Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). Eur J Med Chem. 2018 Dec 11;163:911-931 Authors: Gonçalves PB, Romeiro NC Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major global health problem. Among […]
A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases
https://clinicaltrials.gov/ct2/show/NCT03645434?type=Intr&cond=COPD&phase=01234&lupd_s=10%2F25%2F2018&lupd_d=14&sort=nwst A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases. Condition : Chronic Obstructive Pulmonary Disease Interventions : Drug: AZD8871; Drug: Anoro® Ellipta® Sponsors : AstraZeneca; Parexel Recruiting NCT03645434 Fri, 24 Aug 2018 12:00:00 EDT
Cell-based Therapy for Chronic Obstructive Pulmonary Disease. Rebuilding the Lung
https://www.atsjournals.org/doi/10.1513/AnnalsATS.201808-534MG https://www.ncbi.nlm.nih.gov/pubmed/30759002?dopt=Abstract
Traditional Chinese medicine tonifying kidney therapy (Bu shen) for stable chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis
https://insights.ovid.com/crossref?an=00005792-201812280-00017 https://www.ncbi.nlm.nih.gov/pubmed/30593141?dopt=Abstract Traditional Chinese medicine tonifying kidney therapy (Bu shen) for stable chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis. Related Articles Traditional Chinese medicine tonifying kidney therapy (Bu shen) for stable chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis. Medicine (Baltimore). 2018 Dec;97(52):e13701 Authors: Zhen G, Yingying L, […]
Zapping airway nerves may help COPD patients breathe
https://www.health24.com/Medical/COPD/News/zapping-airway-nerves-may-help-copd-patients-breathe-20180918 Zapping airway nerves may help COPD patients breathe
Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS
https://www.ncbi.nlm.nih.gov/pubmed/30551456 https://www.sciencedirect.com/science/article/pii/S0753332218348315?via%3Dihub Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo
https://clinicaltrials.gov/ct2/show/NCT03636347?type=Intr&cond=COPD&phase=01234&lupd_s=11%2F01%2F2018&lupd_d=14&sort=nwst A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. Conditions : Alpha 1-Antitrypsin Deficiency; Emphysema; COPD Interventions : Drug: Placebo Oral Tablet; Drug: Alvelestat oral tablet – dose 1; Drug: Alvelestat oral tablet – dose 2 Sponsors : Mereo BioPharma; Syneos Health Recruiting NCT03636347 Fri, 17 Aug 2018 12:00:00 EDT
Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
https://clinicaltrials.gov/ct2/show/NCT03449459?type=Intr&cond=COPD&phase=01234&lupd_s=11%2F01%2F2018&lupd_d=14&sort=nwst Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract Condition : Chronic Obstructive Pulmonary Disease (COPD) Interventions : Dietary Supplement: oral probiotics; Drug: aerosol inhaled amikacin; Biological: combined vaccination Sponsors : Shanghai Zhongshan Hospital; The First Affiliated Hospital of Guangzhou Medical University; Ruijin Hospital Not yet recruiting NCT03449459 Wed, 28 Feb 2018 12:00:00 EST
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
https://clinicaltrials.gov/ct2/show/NCT01513655?type=Intr&cond=COPD&phase=01234&lupd_s=11%2F02%2F2018&lupd_d=14&sort=nwst Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Conditions : Chronic Obstructive Pulmonary Disease; Acute Exacerbation of Chronic Obstructive Airways Disease; Chronic Hypercapnic Respiratory Failure Intervention : Device: LTNIV Sponsors : University Hospital, Gentofte, Copenhagen; Philips Respironics Recruiting NCT01513655 Fri, 20 Jan 2012 12:00:00 EST UPDATE: now recruiting
FDA Approves Revefenacin, a Once-a-Day Nebulized LAMA, for COPD
https://www.ajmc.com/newsroom/fda-approves-revefenacin-a-onceaday-nebulized-lama-for-copdFDA Approves Revefenacin, a Once-a-Day Nebulized LAMA, for COPD
Theravance Biopharma and Mylan Receive FDA Approval for YUPELRI™ (revefenacin) in Adults with Chronic Obstructive Pulmonary Disease
https://www.prnewswire.com/news-releases/theravance-biopharma-and-mylan-receive-fda-approval-for-yupelri-revefenacin-in-adults-with-chronic-obstructive-pulmonary-disease-300747672.html
Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells In Chronic Lung Disorders
https://clinicaltrials.gov/ct2/show/NCT02946658?type=Intr&cond=COPD&phase=01234&lupd_s=10%2F25%2F2018&lupd_d=14&sort=nwst Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells In Chronic Lung Disorders Condition : Lung Disease Interventions : Procedure: lipoaspiration; Procedure: ADcSVF; Procedure: Normal Saline IV Sponsors : Healeon Medical Inc; Terry, Glenn C., M.D. Recruiting NCT02946658 Thu, 27 Oct 2016 12:00:00 EDT
A Study to Assess the Efficacy of a 5-day, 10- mg PBF-680 Oral Administration on Late Asthmatic Responses (LAR) in Mild to Moderate Asthmatic Patients
https://clinicaltrials.gov/ct2/show/NCT02635945?type=Intr&cond=COPD&phase=01234&lupd_s=10%2F23%2F2018&lupd_d=14&sort=nwst A Study to Assess the Efficacy of a 5-day, 10- mg PBF-680 Oral Administration on Late Asthmatic Responses (LAR) in Mild to Moderate Asthmatic Patients. Condition : Asthma Interventions : Drug: PBF-680; Drug: Placebo Sponsors : Palobiofarma SL; Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau; […]
Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD
https://clinicaltrials.gov/ct2/show/NCT03655795?type=Intr&cond=COPD&phase=01234&lupd_s=10%2F23%2F2018&lupd_d=14&sort=nwst Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD Condition : COPD Intervention : Biological: Bronchial basal cells Sponsors : Ruijin Hospital; Regend Therapeutics Not yet recruiting NCT03655795 Fri, 31 Aug 2018 12:00:00 EDT
Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP)
https://clinicaltrials.gov/ct2/show/NCT03615040?type=Intr&cond=COPD&phase=01234&lupd_s=10%2F19%2F2018&lupd_d=14&sort=nwst Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP) Condition : COPD Exacerbation Interventions : Drug: MSTT1041A; Drug: Placebo Sponsors : University of Leicester; Biomedical Research Centre- Respiratory (Glenfield Hospital, Leicester UK); Leicester Clinical Trials Unit; Genentech, Inc. Recruiting NCT03615040 Fri, 03 Aug 2018 12:00:00 EDT
Zapping Airway Nerves May Help COPD Patients
https://www.webmd.com/lung/copd/news/20180918/zapping-airway-nerves-may-help-copd-patients#1Zapping Airway Nerves May Help COPD Patients
Testosterone replacement therapy could slow the progression of COPD
Testosterone replacement therapy could slow the progression of COPD Testosterone replacement therapy could slow the progression of COPD
A Pilot Study of the Use of Metformin to Reduce Airway Glucose in COPD
https://clinicaltrials.gov/ct2/show/NCT03651895?type=Intr&cond=COPD&phase=04&sfpd_d=14&sort=nwst&sel_rss=new14 Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death worldwide and affects 1.2 million people in the UK, costing the NHS >£800 million annually. COPD patients are more susceptible to bacterial infections and both chronic and acute infections are common. COPD patients with chronic lung bacterial infection have worse quality of […]
The anti-inflammatory effect of BML-111 on COPD may be mediated by regulating NLRP3 inflammasome activation and ROS production
https://www.sciencedirect.com/science/article/abs/pii/S1098882318300170?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30102962?dopt=Abstract
Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema
https://www.sciencedirect.com/science/article/pii/S0944711318302770?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30668445?dopt=Abstract Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema. Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema. Phytomedicine. 2018 Aug 08;55:70-79 Authors: Kennedy-Feitosa E, Cattani-Cavalieri I, Barroso MV, Romana-Souza B, Brito-Gitirana L, Valenca SS Abstract BACKGROUND: Eucalyptol is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and […]
Endobronchial coil therapy in severe emphysema: 6-month outcomes from a Swiss National Registry
http://jtd.amegroups.com/article/view/20947/17895 https://www.ncbi.nlm.nih.gov/pubmed/30210823?dopt=Abstract J Thorac Dis Endobronchial coil therapy in severe emphysema: 6-month outcomes from a Swiss National Registry. J Thorac Dis. 2018 Aug;10(Suppl 23):S2711-S2718 Authors: Fellrath JM, Scherer T, Franzen DP, Lovis A, von Garnier C, Plojoux J, Soccal PM Abstract Background: Endobronchial coils have been demonstrated in three randomized, controlled trials to improve quality […]
FDA-Approved Valve Treatment For COPD Seeing Positive Results
FDA-Approved Valve Treatment For COPD Seeing Positive Results FDA-Approved Valve Treatment For COPD Seeing Positive Results
FDA approves novel device for treating breathing difficulty from severe emphysema
FDA approves novel device for treating breathing difficulty from severe emphysema https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm612271.htm
Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice
https://link.springer.com/article/10.1007%2Fs10753-018-0811-x https://www.ncbi.nlm.nih.gov/pubmed/29959623?dopt=Abstract Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice. Related Articles Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice. Inflammation. 2018 Oct;41(5):1671-1680 Authors: Meiqian Z, Leying Z, Chang C Abstract The aim of this study was to investigate the effects of Astragaloside IV (AS) on cigarette smoke (CS)-induced chronic obstructive pulmonary disease […]
Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166205/ https://academic.oup.com/aje/article/187/10/2109/4996676 https://www.ncbi.nlm.nih.gov/pubmed/29771274 Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study
MyD88 as a therapeutic target for inflammatory lung diseases
https://www.tandfonline.com/doi/abs/10.1080/14728222.2018.1464139?journalCode=iett20 https://www.ncbi.nlm.nih.gov/pubmed/29658361?dopt=Abstract MyD88 as a therapeutic target for inflammatory lung diseases. Related Articles MyD88 as a therapeutic target for inflammatory lung diseases. Expert Opin Ther Targets. 2018 05;22(5):401-408 Authors: Di Padova F, Quesniaux VFJ, Ryffel B Abstract INTRODUCTION: Myeloid differentiation primary response protein 88 (MyD88) is a critical adaptor protein involved in Toll-like and IL-1 […]
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