https://clinicaltrials.gov/ct2/show/NCT03449459?type=Intr&cond=COPD&phase=01234&lupd_s=11%2F01%2F2018&lupd_d=14&sort=nwst Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract Condition : Chronic Obstructive Pulmonary Disease (COPD) Interventions : Dietary Supplement: oral probiotics; Drug: aerosol inhaled amikacin; Biological: combined vaccination Sponsors : Shanghai Zhongshan Hospital; The First Affiliated Hospital of Guangzhou Medical University; Ruijin Hospital Not yet recruiting NCT03449459 Wed, 28 Feb 2018 12:00:00 EST